The National Trust for Nature Conservation (NTNC), established in 1982 by a Legislative Act, is an autonomous and not-for-profit organization mandated to work in the field of nature conservation in Nepal. Over the past three decades, NTNC has successfully undertaken more than three hundred small and large projects on nature and biodiversity conservation, clean energy and climate change, as well as cultural heritage protection, ecotourism, and sustainable development through active engagement of local communities. NTNC works closely with the Government of Nepal in the management of protected areas by directly managing three mountain protected areas and assisting the government in all the low land parks. Our research outcomes have been especially instrumental in evidence-based decision making at the policy level. The Trust’s experience over the years has shown that conservation efforts in low income economies, such as Nepal, cannot be successful, much less sustainable, unless the needs and welfare of the local people are addressed. Holistic and integrated conservation and development program with active people’s participation aimed at promoting local guardianship have been the focus of our activities.